Nicotinamide Adenine Dinucleotide — Universal Cellular Coenzyme
$230.00 AUD
500mg/vial — the central molecule in longevity research.
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Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every living cell, fundamental to energy metabolism, DNA repair, and cellular signalling. Research over the past two decades has established NAD+ as a critical regulator of aging biology: circulating NAD+ levels decline by approximately 50% between the ages of 40 and 60 in humans, a decline that correlates with many hallmarks of biological aging including mitochondrial dysfunction, genomic instability, and increased inflammation.
Restoring NAD+ levels is now one of the most active areas of longevity research globally. As the obligate co-substrate for sirtuins and PARP enzymes, NAD+ sits at the nexus of energy metabolism, epigenetic regulation, and DNA repair — making it the single most important small molecule in contemporary aging research.
"FOR RESEARCH USE ONLY. This information is provided for scientific and educational purposes only. It does not constitute medical advice or a recommendation for human use."
| Compound | NAD+ (Nicotinamide Adenine Dinucleotide) |
| Form | Lyophilized powder |
| Dosage | 500mg/vial |
| Purity | 99%+ (HPLC verified) |
| Testing | Third-party HPLC + MS |
| Storage | -20°C (long-term) or 2-8°C (short-term) |
| Origin | GMP facility |
NAD+ serves as an electron carrier in the electron transport chain, cycling between its oxidised (NAD+) and reduced (NADH) forms — the fundamental mechanism of cellular energy production. Beyond metabolism, it is the obligate co-substrate for sirtuins (SIRT1–7), the deacylase enzymes that regulate gene expression, mitochondrial biogenesis, inflammatory response, and stress resistance.
NAD+ is also required by PARP-1 (poly ADP-ribose polymerase), the primary DNA repair enzyme, which consumes NAD+ at sites of DNA damage. CD38 and CD157 cyclases also use NAD+ as substrate, and their upregulation with age is believed to be a key driver of NAD+ decline. This multi-layered consumption means NAD+ availability intersects with virtually every aspect of cellular health and aging.
Every batch independently tested via HPLC and Mass Spectrometry. COAs published on site.
Based in Australia with express shipping nationwide. Discreet, temperature-controlled packaging.
Every batch independently tested via HPLC and Mass Spectrometry. COAs published on site with full batch details.
NAD+ declines primarily due to increased consumption by CD38 and PARP enzymes — not reduced synthesis. CD38 (a NADase) increases with age-related inflammation. PARP-1 is activated by accumulating DNA damage. Together, these consume NAD+ faster than the body can replenish it through salvage pathways. Human NAD+ levels drop ~50% between age 40–60.
Two primary delivery routes exist: (1) intravenous injection at 250 mg – 1 g over 2–8 hours for maximum bioavailability, and (2) subcutaneous or intramuscular injection at 50–100 mg per dose. Oral NAD+ itself has poor bioavailability — oral precursors NMN and NR are studied at 250–1000 mg/day.
NAD+ is hygroscopic and light-sensitive. Store lyophilized powder at -20°C for long-term stability or 2–8°C for short-term use. Protect from light and moisture. Once reconstituted, use within 24–48 hours — NAD+ in solution degrades rapidly compared to peptide-based compounds.
NAD+ is legal to purchase for legitimate research purposes in Australia. As a naturally occurring endogenous molecule, it is not a scheduled substance. All sales are strictly for laboratory research purposes — not for human or veterinary consumption.
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