Mitochondrial Peptide — 10mg/vial
$109.00 AUD
Third-party HPLC tested. COA published for every batch.
💧 Need BAC water? 30mL bacteriostatic water available — $21.90 ($13 less than AU competitors). Add to your order.
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-C) is a mitochondrial-derived peptide encoded in the mitochondrial genome. First discovered in 2015, MOTS-C has emerged as a key regulator of metabolism, with significant implications for aging, obesity, diabetes, and exercise physiology research. Unlike traditional peptides that act through cell surface receptors, MOTS-C originates within the mitochondria and can translocate to the nucleus to regulate gene expression under metabolic stress.
This unique mechanism positions MOTS-C as a central mediator of mitochondrial-nuclear communication and metabolic homeostasis. Research shows MOTS-C activates AMPK (AMP-activated protein kinase), enhances glucose uptake, promotes fatty acid oxidation, and improves insulin sensitivity in skeletal muscle.
"FOR RESEARCH USE ONLY. This information is provided for scientific and educational purposes only. It does not constitute medical advice or a recommendation for human use."
| Compound | MOTS-C |
| Form | Lyophilized powder |
| Dosage | 10mg per vial |
| Purity | 99%+ (HPLC verified) |
| Testing | Third-party HPLC + MS |
| Storage | Long-term: -20°C with desiccant |
| Origin | GMP facility |
| Sequence | Met-Lys-Leu-Ile-Phe-Phe-Arg-Leu-Arg-Ser-Gln-Ile-His-Leu |
| Molecular Weight | Approximately 1600 Da |
MOTS-C primarily regulates metabolism through the AMP-activated protein kinase (AMPK) pathway, a central cellular energy sensor. By activating AMPK, MOTS-C promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis while inhibiting lipid synthesis.
Research also demonstrates MOTS-C's ability to regulate nuclear gene expression by translocating to the nucleus under metabolic stress. It affects genes involved in glucose metabolism, antioxidant defense (increasing glutathione and SOD2), and inflammation (reducing NF-κB signaling). Additionally, MOTS-C has been shown to enhance insulin sensitivity in skeletal muscle and promote mitochondrial biogenesis through PGC-1α activation.
• AMPK activation
• Mitochondrial-nuclear communication
• PGC-1α activation
• GLUT4 translocation
• Increased glucose uptake
• Enhanced fatty acid oxidation
• Mitochondrial biogenesis
• Reduced lipid synthesis
Every batch independently tested via HPLC and Mass Spectrometry. COAs published on site with batch-specific purity results.
Based in Australia with express shipping nationwide. Discreet, temperature-controlled packaging ensures peptide integrity.
Priced at $109 for 10mg - competitive vs. main Australian competitor's $120+ for 10mg. Includes free BAC water cross-sell offer.
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-C) is a mitochondrial-derived peptide that regulates metabolism through AMPK activation, enhances insulin sensitivity, promotes mitochondrial biogenesis, and influences mitochondrial-nuclear communication. It has significant implications for aging, obesity, diabetes, and exercise physiology research.
MOTS-C is commonly administered subcutaneously in preclinical research. Standard research protocols use 5-10 mg/kg for mice, translating to approximately 0.3-0.6 mg for human equivalent dosing. Always follow your institution's ethical guidelines and consult with qualified professionals for research protocols.
Research demonstrates MOTS-C's ability to: improve glucose tolerance, enhance insulin sensitivity, promote fatty acid oxidation, increase exercise endurance, regulate mitochondrial function, reduce oxidative stress, influence aging-related pathways, and show protective effects in models of neurodegenerative diseases.
MOTS-C is legal to purchase for legitimate research purposes in Australia. It is not a scheduled substance when intended for laboratory research use only. All sales are strictly for research purposes — not for human or veterinary consumption.
For long-term storage, keep lyophilized MOTS-C at -20°C with desiccant. For short-term storage (weeks), refrigerate at 2-8°C. Once reconstituted, use immediately or aliquot and store at -80°C to avoid freeze-thaw cycles.