Mitochondrial Peptide — 5mg/vial
$99 AUD
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MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide encoded within the mitochondrial genome — not the nuclear genome. Discovered in 2015 by the USC Leonard Davis School of Gerontology, MOTS-C has rapidly become one of the most studied mitochondrial peptides in metabolic research.
Unlike most peptides encoded by nuclear DNA, MOTS-C is transcribed directly from mitochondrial DNA. Preclinical research suggests it plays a key role in metabolic regulation: activating AMPK (AMP-activated protein kinase), improving insulin sensitivity, promoting glucose uptake, and acting as an exercise mimetic. Its unique origin in the mitochondrial genome has made it a compound of significant interest across metabolic disease, aging, and exercise physiology research.
"FOR RESEARCH USE ONLY. This information is provided for scientific and educational purposes only. It does not constitute medical advice or a recommendation for human use."
| Compound | MOTS-C |
| Form | Lyophilized powder |
| Dosage | 5mg/vial |
| Purity | 99%+ (HPLC verified) |
| Testing | Third-party HPLC + MS |
| Storage | 2-8°C (refrigerated) |
| Origin | GMP facility |
MOTS-C's primary mechanism involves AMPK activation in skeletal muscle, liver, and adipose tissue. This triggers a cascade of metabolic effects: increased glucose uptake, enhanced fatty acid oxidation, and improved mitochondrial biogenesis. Notably, MOTS-C acts through a mechanism distinct from metformin (the gold-standard AMPK activator), suggesting potential for combinatorial research applications.
Research also demonstrates that MOTS-C regulates insulin sensitivity through modulation of the insulin signalling pathway (Akt phosphorylation). In cellular models, MOTS-C treatment improves glucose metabolism and reduces lipid accumulation. The peptide has also been implicated in regulating the NAD+/NADH ratio, linking mitochondrial function to cellular energy status.
Unlike nuclear-encoded peptides, MOTS-C's unique origin in the mitochondrial genome positions it as both a signalling molecule and a potential regulator of mitochondrial stress responses. This dual role makes it particularly relevant for research in age-related metabolic decline, exercise physiology, and metabolic disorders.
Every batch independently tested via HPLC and Mass Spectrometry. COAs published on site.
Based in Australia with express shipping nationwide. Discreet, temperature-controlled packaging.
Every batch independently tested via HPLC and Mass Spectrometry. COAs published on site with full batch details.
MOTS-C activates AMPK (AMP-activated protein kinase) in skeletal muscle and metabolic tissues, promoting glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. It also regulates insulin sensitivity through Akt phosphorylation and modulates the NAD+/NADH ratio. This multi-pathway mechanism distinguishes it from single-target metabolic compounds.
Unlike nuclear-encoded peptides, MOTS-C is transcribed directly from mitochondrial DNA (the 12S rRNA-c open reading frame). This unique origin positions it as both a mitochondrial signalling molecule and a regulator of systemic metabolism. It acts as an exercise mimetic — inducing metabolic changes resembling those seen during physical activity — which is a distinct profile from peptides like GHRP-6 or IGF-1.
MOTS-C research commonly uses subcutaneous or intraperitoneal injection. Doses in animal studies typically range from 10-20 mg/kg/day. In cellular research, concentrations of 10-100 µM are standard. The peptide is water-soluble and reconstituted with sterile bacteriostatic water. Always follow your institution's ethical guidelines.
MOTS-C is legal to purchase for legitimate research purposes in Australia. It is not a scheduled substance when intended for research use only. All sales are strictly for laboratory research purposes — not for human or veterinary consumption.
MOTS-C demonstrates good stability as a lyophilized powder when stored at 2–8°C. Once reconstituted with bacteriostatic water, it should be used within 7–14 days. The peptide's tuftsin-derived structure contributes to its favourable stability compared to some other short peptides.
MOTS-C is legal to purchase for legitimate research purposes in Australia. It is not a scheduled substance when intended for research use only. All sales are strictly for laboratory research purposes — not for human or veterinary consumption.
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